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Triptolide also reduced F- actin polymerization, which was related to the inhibition of MAPK signaling pathway activation (reducing TNF--induced phosphorylation of JNK) (97)

When taken orally, they face two major obstacles: Stomach acid: Hydrochloric acid (pH 1.5-3.5) denatures peptide bonds, breaking the molecule into inactive fragments before it can be absorbed Digestive enzymes: Pepsin, trypsin, and chymotrypsin in the stomach and small intestine specifically target peptide bonds for cleavage

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